Yes, you can check in anything you like as long as the airline is reasonably assured that a) it contains nothing nefarious/dangerous, and b) will survive the trip without disintegrating into bits along the way.

However, what are you hoping to accomplish with the bubble wrap? The original cardboard box and its Styrofoam inserts have already been designed to provide all the protection necessary for its long journey from the factory in China to wherever you bought it, and are thus likely more than sufficient for a flight or two. Simple plastic wrapping might be worth it if you're concerned about theft, somebody sneaking in a kilo of cocaine, water damage etc, but none of these except maybe the last seem terribly likely on a US domestic flight.

Yes, you can check in anything you like as long as the airline is reasonably assured that a) it contains nothing nefarious/dangerous, and b) will survive the trip without disintegrating into bits along the way.

However, what are you hoping to accomplish with the bubble wrap? The original cardboard box and its Styrofoam inserts have already been designed to provide all the protection necessary for its long journey from the factory in China to wherever you bought it, and are thus likely more than sufficient for a flight or two. Simple plastic wrapping might be worth it if you're concerned about theft, somebody sneaking in a kilo of cocaine, water damage etc, but none of these except maybe the last seem terribly likely on a US domestic flight.