Do you think it is a plus point or can go against me if I say NO to "Do you have friends or family in UK".
The truthful answer to this is 'yes', but you would like to answer 'no' because to answer truthfully involves going in to detail. This is going to be a easy one. Let's look at the head note to Kenya  UKUT 165 (IAC)...
“When a direct question is asked, and answered untruthfully, there is
both a false representation and a non-disclosure; and it is not open
to an Appellant who gives an untruthful answer to a direct question in
an application form to say that the matter was not material.”
What this means is that if you get caught there will be very little room to argue that you were justified in answering 'no' in order to avoid giving details.
So on that basis, it would not be a 'plus point' if you answer 'no' and they find out that someone else in your family (for example) had previously answered 'yes' or they learned through some other way.
It's actually difficult to find an internet resource that recommends lying on a UK visa application, and this site is no different. Avoid deception.
Note: screen shot of the guidance...