I'm from Brazil and I'm planning to fly to Panama and then take a bus from Panama City to Medellin, is it possible?
Direct flights are so expensive!
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There is no road connecting the two countries. Briefly and recently, a ferry ran between Panama and Colombia. However, it seems it is no longer available: Their Facebook page is empty, their website is suspended. Outdated information at Wikioverland suggests the ferry didn't run for most of 2015 either.