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This question already has an answer here:

I'm from Brazil and I'm planning to fly to Panama and then take a bus from Panama City to Medellin, is it possible?

Direct flights are so expensive!

marked as duplicate by Michael Hampton, blackbird, Willeke, Community Jan 20 '16 at 5:28

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    The linked question should give you some idea of how to travel between Panama and Colombia without flying. But the gist of it is, that there's no road between Panama and Colombia (known as the Darien Gap) and thus it will be hard to take a bus. – drat Jan 19 '16 at 8:12
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    There are no buses, because there are no roads! – Michael Hampton Jan 19 '16 at 11:54
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Currently, no.

There is no road connecting the two countries. Briefly and recently, a ferry ran between Panama and Colombia. However, it seems it is no longer available: Their Facebook page is empty, their website is suspended. Outdated information at Wikioverland suggests the ferry didn't run for most of 2015 either.

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