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I know there are buses running between Istanbul Turkey and Tbilisi Georgia.
I know they take about 30 hours and cost about $35.
What I don't know is what time they depart Tbilisi and what time roughly they arrive in Istanbul.
I also don't know whether there is just one company or several, and whether they leave from Ortachala or Didube station or some from each.
Following my own advice from my answer to Is there an equivalent to “The Man in Seat Sixty-One” for bus travel?, I looked on the Lonely Planet page for Tbilisi:
A minifleet of four or five buses run by different companies departs at noon for Istanbul (US$40, 27 hours) via the border at Sarpi, Hopa, Rize
They leave from the second bus terminal:
Ortachala bus station (753433; Gulia 1) is something of a backwater, about 2.5km southeast of the Old Town.
