The number of fatalities caused by a certain airline does NOT reflect how safe that airline is. The number of fatalities can be very high due to a single accident which is caused by reasons not related to the safety of the airline in question.
Usually people tend to think of safety only when it comes to airplanes, this is wrong. The safety of an airline is much more than that, it is embedded in every single thing, it is more of a culture than just a bunch of policies and procedures.
In general, I would rather fly in a twenty-year-old Ryanair airplane than in a one-year-old plane in an African airline. Why is that? EU civil authorities have very strict policies and procedures, lately they've even started forcing the new safety principle called SMS (Safety Management System) which simply involves all parts of the airlines in the safety, including the higher management since the first principle of this system is to put the liability and responsibility on the higher management instead of just blaming some employee when something happens under (human error).
Also, the random checks conducted by the EU authorities are a pain in the ass to all airlines, they are brutal and serious. They will have no problem issuing all kinds of punishments if they have a finding, including suspending the airline. I personally deal with this stuff in my job and I know how good they are.
Talking of crew duty hours, just to let you know, as a crew member for long time I met a lot of crew members from all over the world, we all have the same complaint (duty hours). It is a universal thing for crew members to complain about. That's due to the anti-routine schedules where crew members have to work weekends and holidays and nights etc. But AFAIK, in EU crew members can not exceed 100 credit hours per month, and that's even less than in the US or the middle east where crew members can fly up to 120 credit hours.
One more thing, crew members who fly for domestic or regional airlines, such as Ryanair, tend to complain more about working hours because they need more flights to reach the 100 credit hours, unlike flying for international airlines, where you can make the same amount of credit hours in 4 or 5 long-haul flights. When I first joined I needed like forty domestic legs to reach 70 hours, but once I had enough seniority I could make the same by flying three flights to the US only!
Bottom line, EU civil authorities are the best when it comes to the safety of different airlines, either the EU ones or the foreign ones that fly to the EU. So, having permission to operate in the EU is enough proof that the airline is safe enough. This is my opinion as a safety person.