I am a Nigerian and I received an invitation from my uncle to visit him. I am applying for a US visitor visa. I have been rejected 3 times when I was single. Now I am married with a child, but have never travelled outside of my country before. What are my chances of getting the visa?
Is it possible to get a US visa if I have no travel history?
Yes. My first travel experience was as a visitor to the USA from Ghana which has a pretty similar profile to Nigeria in many respects including immigration statistics to western countries.
That said, your chances of getting a USA visa as your first travel experience after three successive rejections are very very very slim. On average, Nigerians have a 44.95% adjusted refusal rate when they apply for USA visitor visas, which is already on the high side. Without knowing (nor needing) any more information about you except what you provided here, I would say your probability of refusal is much higher than the average, maybe two times worse.
My advice to you is to build a travel history in a systematic manner then after a few years you can apply for a USA visa.
According to what I've seen by many friends and family members applying U.S. visa, the most important thing they check is ... ties to your country or country of residence compared to reasons to stay in the U.S.
Having a stable job in a big company for several years is a big plus to get USA visa. Travel history also have a positive factor, especially traveling to developed countries. Family ties are important too but other than your spouse and your kids, I think other family does not weigh in much for your visa application.