I love rolling my clothes! You can get your clothing into the nooks and crannies created by the suitcase and books. The suitcase is most likely to be handled in the standing/rolling position so I typically lay the heaviest items at the bottom of the suitcase. When gravity takes place, the heavy items won't squish all my clothing/toiletries.
Pack travel friendly clothing/wrinkle spray
My other suggestion is packing travel friendly clothing (synthetic materials). Anti-wrinkle or wrinkle resistant travel clothes are a life saver. Using fabric softeners should also help prevent extreme wrinkling beforehand.
If you can't forego cottons and other materials that wrinkle easily (cotton, rayon, linen) then look into some wrinkle relaxing spray. The gist is to hang and spray the clothing. Then after a few minutes, the wrinkles should relax. Another trick is allowing the clothing to hang in the bathroom while you take a hot steamy shower. There are other DIY and tricks on how to make your own spray but at your own risk!
Look into travel clothing bags to preserve your best clothing. These should be secured flat on top of everything else. Some suitcases have those elastic bands inside for this purpose. Sometimes I use compression bags to keep clothing flat.
These won't replace having to iron your clothes but if you can pack effectively, you'll be able to prevent the worst. Some hotels, hostels, or air bnbs may offer irons as part of their service if you inquire ahead of time.
Travel clothing and compression bags can be found at travel stores like Tilly, Columbia, Mountain Equipment Coop, Travel Smith, etc...